Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Solitary Fibrous Tumor, Mediastinal

  • Shaoxiong Chen
  • Sunil Badve
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-66796-6_51

Definition

Solitary fibrous tumor (SFT) is usually a well-circumscribed mesenchymal tumor consisting of haphazardly arranged bland spindle cells, thick collagen stroma, and at least focal areas of branching hemangiopericytoma-like blood vessels with biological behavior ranging from benign to malignant.

Although SFT was originally known as a neoplasm of pleura, other serosal surfaces, or mediastinum, it can be found essentially in any location including the meninges. Studies of SFT of the pleura using immunostaining, flow cytometric analysis, and electron microscopy have indicated that SFT likely originates from a submesothelial cell, which has been variably considered to be a mesenchymal cell, a primitive multipotential cell, or a primitive fibroblast. Mediastinal SFT can arise in the thymic tissue and show no involvement of the pleura. It is often detected incidentally by an imaging study performed for an unrelated condition. Symptomatic patients commonly present with cough, chest...

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References and Further Reading

  1. Cardillo, G., Lococo, F., Carleo, F., & Martelli, M. (2012). Solitary fibrous tumors of the pleura. Current Opinion in Pulmonary Medicine, 18(4), 339–346.CrossRefPubMedGoogle Scholar
  2. Doyle, L. A., Vivero, M., Fletcher, C. D., Mertens, F., & Hornick, J. L. (2014). Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Modern Pathology, 27(3), 390–395.CrossRefPubMedGoogle Scholar
  3. van de Rijn, M., Lombard, C. M., & Rouse, R. V. (1994). Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung. American Journal of Surgical Pathology, 18(8), 814–820.CrossRefPubMedGoogle Scholar
  4. Witkin, G. B., & Rosai, J. (1989). Solitary fibrous tumor of the mediastinum. A report of 14 cases. American Journal of Surgical Pathology, 13(7), 547–557.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineIndiana University School of MedicineIndianapolisUSA