Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Schwannoma, Mediastinal

  • Shaoxiong ChenEmail author
  • Sunil Badve
Reference work entry




Mediastinal schwannoma is a benign, slow-growing lesion arising from Schwann cells of the spinal nerves. It can also involve any thoracic nerve. Histologically, it is characterized by the presence of a highly organized cellular component (Antoni A) and a loosely myxoid component (Antoni B). A small percentage of patients experience paresthesia or pain due to tumor compression or intraspinal tumor extension.

Clinical Features

  • Incidence

    Schwannoma is the most common neurogenic neoplasm in the mediastinum. Approximately 20% of all adult and 35% of all pediatric mediastinal neoplasms are neurogenic tumors, which include schwannoma, neurofibroma, neuroblastoma, ganglioneuroblastoma, ganglioneuroma, paraganglioma, etc. Approximately 90% of neurogenic tumors are located in the posterior mediastinum. They make up 75% of primary posterior mediastinal neoplasms.

  • Age

    Mediastinal schwannomas most commonly occur in patients ranging in age from 21 to 40 years old. In...

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References and Further Reading

  1. Miettinen, M. (2010). Modern soft tissue pathology: Tumors and non-neoplastic conditions. New York: Cambridge University Press.CrossRefGoogle Scholar
  2. Reed, J. C., Hallet, K. K., & Feigin, D. S. (1978). Neural tumors of the thorax: Subject review from the AFIP. Radiology, 126(1), 9–17.CrossRefPubMedGoogle Scholar
  3. Strollo, D. C., Rosado-de-Christenson, M. L., & Jett, J. R. (1997). Primary mediastinal tumors: Part II. Tumors of the middle and posterior mediastinum. Chest, 112(5), 1344–1357.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineIndiana University School of MedicineIndianapolisUSA