Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Pleomorphic Lymphoma, Mediastinal

  • Horatiu OlteanuEmail author
Reference work entry


Pleomorphic large cell lymphoma of the mediastinum


Pleomorphic large cell lymphoma of the mediastinum (PLCLM) is a B-cell non-Hodgkin lymphoma characterized by a neoplastic cell population that does not morphologically resemble lymphoid cells and rather simulates a sarcoma or anaplastic carcinoma.

Clinical Features

  • Incidence

    PLCLM is an uncommon neoplasm; in a series of 120 primary large cell lymphomas of the mediastinum collected over a period of 20 years, nine cases (7.5%) with morphologic features of PLCLM were identified (Suster and Moran 1996).

  • Age

    Adults are most commonly affected, with a mean age at presentation of 51 years (range, 30–65 years, in a series of nine cases).

  • Sex

    Males and females are almost equally represented in those diagnosed with PLCLM.

  • Site

    Clinically, patients present with a mediastinal mass, which commonly extends into the organs from its vicinity, such as mediastinal vessels, lungs, and cervical lymph nodes and soft tissue. The tumor is...

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References and Further Reading

  1. Calvo, K. R., Traverse-Glehen, A., Pittaluga, S., & Jaffe, E. S. (2004). Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: Implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. Advances in Anatomic Pathology, 11(5), 227–238.CrossRefPubMedGoogle Scholar
  2. Suster, S. (1999). Primary large-cell lymphomas of the mediastinum. Seminars in Diagnostic Pathology, 16(1), 51–64.PubMedGoogle Scholar
  3. Suster, S., & Moran, C. A. (1996). Pleomorphic large cell lymphomas of the mediastinum. American Journal of Surgical Pathology, 20(2), 224–232.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Medical College of WisconsinMilwaukeeUSA
  2. 2.Department of Pathology, Mayo ClinicRochesterUSA