Pleomorphic Lymphoma, Mediastinal
Pleomorphic large cell lymphoma of the mediastinum
Pleomorphic large cell lymphoma of the mediastinum (PLCLM) is a B-cell non-Hodgkin lymphoma characterized by a neoplastic cell population that does not morphologically resemble lymphoid cells and rather simulates a sarcoma or anaplastic carcinoma.
PLCLM is an uncommon neoplasm; in a series of 120 primary large cell lymphomas of the mediastinum collected over a period of 20 years, nine cases (7.5%) with morphologic features of PLCLM were identified (Suster and Moran 1996).
Adults are most commonly affected, with a mean age at presentation of 51 years (range, 30–65 years, in a series of nine cases).
Males and females are almost equally represented in those diagnosed with PLCLM.
Clinically, patients present with a mediastinal mass, which commonly extends into the organs from its vicinity, such as mediastinal vessels, lungs, and cervical lymph nodes and soft tissue. The tumor is...
References and Further Reading
- Calvo, K. R., Traverse-Glehen, A., Pittaluga, S., & Jaffe, E. S. (2004). Molecular profiling provides evidence of primary mediastinal large B-cell lymphoma as a distinct entity related to classic Hodgkin lymphoma: Implications for mediastinal gray zone lymphomas as an intermediate form of B-cell lymphoma. Advances in Anatomic Pathology, 11(5), 227–238.CrossRefPubMedGoogle Scholar