Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Biphasic Diffuse Malignant Mesothelioma, Pleural

  • Mohamed Khalil
  • Timothy Craig AllenEmail author
Reference work entry


Biphasic diffuse malignant mesothelioma; Biphasic/mixed DMM; Mixed diffuse malignant mesothelioma


Diffuse malignant mesothelioma (DMM) is an aggressive neoplasm of the pleura, usually in individuals with history of asbestos exposure. MM is the most common primary tumor of the pleura, presenting as diffuse mass that is identifiable clinically. DMM should be distinguished from the more favorable prognosis of localized malignant mesothelioma and well-differentiated papillary malignant mesothelioma.

The 2015 World Health Organization (WHO) Classification of Tumors of the Pleura classified the major histologic types of DMM as epithelioid, sarcomatoid (desmoplastic), and biphasic mesothelioma.

Clinical Features

  • Incidence

    Biphasic DMM is the second most common histologic variant of pleural malignant mesothelioma, accounting for 20–35% of the cases (epithelioid and sarcomatoid accounting for approximately 60% and 20% of cases, respectively).

  • Age

    The average age at the time...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Arif, Q., & Husain, A. N. (2015). Malignant mesothelioma diagnosis. Archives of Pathology and Laboratory Medicine, 139(8), 978–980. Scholar
  2. Galateau-Salle, F., et al. (2016). The 2015 world health organization classification of tumors of the Pleura: Advances since the 2004 classification. Journal of Thoracic Oncology, 11(2), 142–154.CrossRefPubMedGoogle Scholar
  3. Husain, A. N., Colby, T. V., Ordóñez, N. G., Allen, T. C., Attanoos, R. L., Beasley, M. B., Butnor, K. J., Chirieac, L. R., Churg, A. M., Dacic, S., Galateau-Sallé, F., Gibbs, A., Gown, A. M., Krausz, T., Litzky, L. A., Marchevsky, A., Nicholson, A. G., Roggli, V. L., Sharma, A. K., Travis, W. D., Walts, A. E., & Wick, M. R. (2017). Guidelines for pathologic diagnosis of malignant mesothelioma: 2017 update of the consensus statement from the international mesothelioma interest group. Archives of Pathology and Laboratory Medicine.
  4. Inai, K. (2008). Pathology of mesothelioma. Environmental Health and Preventive Medicine, 13(2), 60–64. Scholar
  5. Oviedo, S. P., & Cagle, P. T. (2012). Diffuse malignant mesothelioma. Archives of Pathology and Laboratory Medicine, 136(8), 882–888. Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.University of Texas Medical Branch in GalvestonGalvestonUSA
  2. 2.Department of PathologyThe University of Mississippi Medical School, The University of Mississippi Medical CenterJacksonUSA