Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Separation of Benign and Malignant Spindle Cell Proliferations in the Pleura

  • Brandon T. LarsenEmail author
Reference work entry


Benign lesions:

Acute and organizing fibrinous pleuritis: Empyema

Chronic fibrosing pleuritis: Fibrohyaline pleuritis; Fibrous pleurisy; Diffuse pleural fibrosis

Hyaline pleural plaque: Fibrohyaline plaque

Calcifying tumor of the pleura: Calcifying fibrous pseudotumor

Borderline lesions:

Solitary fibrous tumor: SFT; Localized fibrous tumor

Deep fibromatosis: Desmoid-type fibromatosis; Desmoid tumor

Inflammatory myofibroblastic tumor: IMT; plasma cell granuloma

Malignant lesions:

Sarcomatoid carcinoma: Spindle cell carcinoma

Sarcomatoid mesothelioma: Spindle cell mesothelioma; Desmoplastic mesothelioma

Synovial sarcoma, monophasic type: SS


Benign spindle cell pleural proliferations include various nonneoplastic and reactive conditions, including acute and organizing fibrinous pleuritis, chronic fibrosing pleuritis, hyaline pleural plaque, and calcifying tumor of the pleura, among others. Borderline spindle cell pleural proliferations include various neoplastic...

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References and Further Reading

  1. Attanoos, R. L., Griffin, A., & Gibbs, A. R. (2003). The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium. A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2. Histopathology, 43(3), 231–238.CrossRefPubMedGoogle Scholar
  2. Betta, P. G., Magnani, C., Bensi, T., Trincheri, N. F., & Orecchia, S. (2012). Immunohistochemistry and molecular diagnostics of pleural malignant mesothelioma. Archives of Pathology and Laboratory Medicine, 136(3), 253–261.CrossRefPubMedGoogle Scholar
  3. Husain, A. N., Colby, T., Ordonez, N., Krausz, T., Attanoos, R., Beasley, M. B., Borczuk, A. C., Butnor, K., Cagle, P. T., Chirieac, L. R., Churg, A., Dacic, S., Fraire, A., Galateau-Salle, F., Gibbs, A., Gown, A., Hammar, S., Litzky, L., Marchevsky, A. M., Nicholson, A. G., Roggli, V., Travis, W. D., Wick, M., & International Mesothelioma Interest Group. (2013). Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Archives of Pathology and Laboratory Medicine, 137(5), 647–667.CrossRefPubMedGoogle Scholar
  4. Travis, W. D. (2010). Sarcomatoid neoplasms of the lung and pleura. Archives of Pathology and Laboratory Medicine, 134(11), 1645–1658.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Mayo ClinicRochesterUSA