Pleuritis is a reactive condition or inflammation of the pleura. The pleura consists of two layers of mesothelium: the visceral layer, which covers the lung parenchyma, and the parietal layer, which lines the thoracic cavity. A minimal amount of fluid is present in the pleural space between these two layers to create a smooth, lubricated surface during breathing. Pleuritis may result in a roughening or irritation of the pleural layers, causing friction during breathing. As the parietal pleura has a rich supply of nerves, this can result in pain, or pleurodynia, usually during inspiration. There are many different causes of pleuritis, depending on the specific form in which it presents, including infection, conditions affecting the thoracic cavity, pulmonary embolism, autoimmune disorders, asbestos-related disease, uremia, medications, and malignancies affecting the lung or pleura.
Granulomatous pleuritis may present in cases of tuberculosis,...
References and Further Reading
- Cagle, P. T. (2007). Color atlas and text of pulmonary pathology (2nd ed.). Philadelphia: Lippincott, Williams & Wilkins.Google Scholar
- Husain, A. N. (2012). Thoracic pathology. Philadelphia: Elsevier/Saunders.Google Scholar
- Lee-Chiong, T., Gebhart, G. F., & Matthay, R. A. (2010). Chest pain. In R. J. Mason, V. C. Broaddus, T. R. Martin, et al. (Eds.), Murray and Nadel’s textbook of respiratory medicine (5th ed.). Philadelphia: Saunders/Elsevier. Chapter 30.Google Scholar