Pathology of the Pleura and Mediastinum

2018 Edition
| Editors: Timothy Craig Allen, Saul Suster

Teratoma, Mediastinal with Malignant Component

  • Ronda Sanders
  • Merce JordaEmail author
Reference work entry

Teratomas are composed of at least two of the three germ cell layers which include ectoderm, mesoderm, and endoderm. The mediastinum is the second most common place to find teratomas with the gonads being the most common (Bremmer and Strobel 2016). Malignant component means the teratoma contains malignant tissue. There are three histological forms of malignant teratomas which include: immature teratoma, teratoma with other malignant germ cell component/s (malignant mixed germ cell tumors), and teratoma with somatic (carcinomatous) malignant transformation.

Mediastinal teratomas with malignant component are very rare and can be divided into two etiologic subgroups which consist of those induced by chemotherapy and/or radiation and the ones that occur spontaneously (Kim and Kim 2013). In postpuberty adults, almost all mediastinal teratomas with malignant component occur in males (Bremmer and Strobel 2016). Genetically, Klinefelter’s syndrome (XXY) has been shown to be associated with...

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References and Further Reading

  1. Athanasiou, A., Vanel, D., El, M. O., Theodore, C., & Fizazi, K. (2009). Non-germ cell tumours arising in germ cell tumours (teratoma with malignant transformation) in men: CT and MR findings. European Journal of Radiology, 69(2), 230–235.CrossRefPubMedGoogle Scholar
  2. Bremmer, F., & Strobel, P. (2016 Sep). Mediastinal germ cell tumors. Der Pathologe, 37(5), 441–448.CrossRefPubMedGoogle Scholar
  3. Donadio, A. C., Motzer, R. J., Bajorin, D. F., Kantoff, P. W., Sheinfeld, J., Houldsworth, J., Chaganti, R. S., & Bosl, G. J. (2003). Chemotherapy for teratoma with malignan transformation. Journal of Clinical Oncology, 21, 4285–4291.CrossRefPubMedGoogle Scholar
  4. El, M. O., Terrier-Lacombe, M. J., Rebischung, C., Theodore, C., Vanel, D., & Fizazi, K. (2007). Chemotherapy in patients with teratoma with malignant transformation. European Urology, 51, 1306–1311.CrossRefGoogle Scholar
  5. Khurana, A., Mehta, A., & Kamboj, M. (2011). Colonic-type adenocarcinoma (somatic-type malignancy) arising in a mediastinal mature cystic teratoma: A case report of a rare entity. Indian Journal of Pathology & Microbiology, 54, 199–200.CrossRefGoogle Scholar
  6. Kim, H. J., & Kim, H. R. (2013). Naturally occurring mediastinal teratoma with malignant transformation in an adult male. The Korean Journal of Thoracic and Cardiovascular Surgery, 46(4), 305–308.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Lin, C., Du, Y., Li, Y., Wang, H., & Chang, J. (2016). Superior mediastinal mature cystic teratoma with gastrointestinal adenocarcinoma transformation: Report of a case. Oncotarget, 7(25), 38392–38397.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Department of UrologyUniversity of Miami Miller School of MedicineMiamiUSA