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Signal Transduction Changes in Human Neutrophils with Age

  • Carl FortinEmail author
  • Tamas Fulop
  • Anis Larbi
  • Gilles Dupuis
Living reference work entry

Abstract

The role of innate immune cells as first line of defense against pathogens and foreign invasion has been widely recognized. Among the innate immune cells, neutrophils represent the most potent phagocytic cell and possess an elaborate arsenal capable of efficiently neutralizing pathogens; in addition, neutrophils modulate adaptive immunity by secreting cytokines. Over the years, it has become clear that human aging negatively affects neutrophils’ responses. A common alteration underlying these functional changes in aging is the decrease of phosphorylated forms of signaling molecules after receptor engagement. The consequences of aging on human neutrophils may impair the activation of immune responses and contribute to poorer vaccine responses and greater morbidity and mortality from infectious diseases in older adults. This chapter describes our current knowledge of the age-related alterations in receptors for the Nformyl-met-leu-phe (fMLP) peptide, for the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), and for Toll-like receptors (TLR) and triggering receptor expressed on myeloid cells-1 (TREM-1).

Keywords

Aging Human neutrophils Signal transduction N-formyl-met-leu-phe peptide receptor GM-CSF receptor TREM-1 receptor Lipid rafts 

Notes

Acknowledgments

We apologize to members of the scientific community whose contributions could not be cited. This work was supported by a grant-in-aid from the National Science and Engineering Research Council of Canada (No 249549), Research Center on Aging of Sherbrooke, the ImAginE Consortium, and the Canadian Institute of Health Research (No 63149).

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Carl Fortin
    • 1
    Email author
  • Tamas Fulop
    • 1
  • Anis Larbi
    • 2
  • Gilles Dupuis
    • 3
  1. 1.Division of Geriatric Medicine, Department of Medicine, Research Center on AgingUniversité de SherbrookeSherbrookeCanada
  2. 2.Singapore Immunology Network (SIgN), Aging and Immunity ProgramAgency for Science Technology and Research (A*STAR)SingaporeSingapore
  3. 3.Immunology Programme, Department of Biochemistry, Faculty of Medicine and Health SciencesUniversity of SherbrookeSherbrookeCanada

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