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Lymphocyte Subtypes and Functions in Centenarians as Models for Successful Aging

  • Elena Bianchini
  • Simone Pecorini
  • Sara De Biasi
  • Lara Gibellini
  • Milena Nasi
  • Andrea CossarizzaEmail author
  • Marcello Pinti
Living reference work entry

Abstract

Several cell subsets participate to the immune response, and their close interplay is fundamental for the successful elimination of harmful pathogens. Immune system undergoes a progressive and profound remodeling of its functions with aging. This process is evidenced by a continuous change in the relative percentages, absolute number, and functionality of the subsets of lymphocytes that ultimately form the immune system.

In this chapter, we describe the main changes in lymphocyte subtypes and functions that occur with age, paying particular attention to centenarians, exceptional individuals who reach the extreme limits of human life in good state of health. A particular emphasis is dedicated to changes observed in particular subsets, like regulatory T cells, invariant natural killer T cells, or mucosal-associated invariant T cells, whose role in many chronic inflammatory diseases or autoimmune diseases has been recently evidenced.

Keywords

Centenarians Polychromatic flow cytometry Successful aging Treg 

Notes

Acknowledgments

Sara De Biasi is an International Society for Advancement of Cytometry (ISAC) Marylou Ingram Scholar.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Elena Bianchini
    • 1
  • Simone Pecorini
    • 2
  • Sara De Biasi
    • 3
  • Lara Gibellini
    • 1
  • Milena Nasi
    • 1
  • Andrea Cossarizza
    • 4
    Email author
  • Marcello Pinti
    • 5
  1. 1.Department of Surgery, Medicine, Dentistry and Morphological SciencesUniversity of Modena and Reggio EmiliaModenaItaly
  2. 2.Department of Biomedical, Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly
  3. 3.Department of Life SciencesUniversity of Modena and Reggio EmiliaModenaItaly
  4. 4.Department of Medical and Surgical Sciences of Children and AdultsUniversity of Modena and Reggio EmiliaModenaItaly
  5. 5.Department of Life SciencesUniversity of Modena and Reggio EmiliaModenaItaly

Section editors and affiliations

  • Tamas Fulop
    • 1
  1. 1.Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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