Immune Senescence and Inflammaging in Neurological Diseases

  • Pascale Baden
  • Silvia De Cicco
  • Cong Yu
  • Michela Deleidi
Living reference work entry


Aging predisposes to disease via several mechanisms that in part converge on inflammatory pathways. As we age, the immune system undergoes a process of senescence accompanied by a chronic inflammatory environment named as “inflammaging”. Emerging evidence suggests that immune senescence also affects the central nervous system and promotes neuronal dysfunction and disease. This chapter focuses on immune senescence and inflammaging and their potential role in the etiopathogenesis of neurological diseases. A better understanding of the mechanisms involved in age-related immune dysfunction may help design novel therapeutic strategies to promote healthy brain aging and treat neurological disorders.


Brain-immune interactions Aging Immunosenescence Inflammation Neurological diseases 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Pascale Baden
    • 1
    • 2
  • Silvia De Cicco
    • 1
    • 2
  • Cong Yu
    • 1
    • 2
  • Michela Deleidi
    • 1
    • 2
    • 3
    • 4
  1. 1.German Center for Neurodegenerative Diseases (DZNE)TübingenGermany
  2. 2.Center of Neurology, Hertie Institute for Clinical Brain Research, University of TübingenTübingenGermany
  3. 3.“Mitochondria and Inflammation in Neurodegenerative Diseases”German Center for Neurodegenerative Diseases (DZNE) Tübingen within the Helmholtz AssociationTübingenGermany
  4. 4.Department of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany

Section editors and affiliations

  • Tamas Fulop
    • 1
  1. 1.Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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