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Aging and Malignant Hemopathies: A Complex Multistep Process

  • Vu Luan Dang Chi
  • Catherine Sibille
  • Karen Willard-Gallo
  • Dominique Bron
Living reference work entry

Abstract

The probability of developing cancer, primarily malignant hemopathies, increases with age. This complex relationship between cancer and aging has been extensively studied; cellular senescence, a protective mechanism in response to DNA damage, can induce permanent growth arrest and resistance to apoptosis. Chronological age also favors the accumulation of genetic and epigenetic changes that are important contributing factors in the complex pathogenesis of cancer. Other age-related mechanisms such as impairment of cancer prevention and clonal restriction of hematopoietic stem cells also lead to the development of cancer. However, a full understanding of the process of aging is far from complete with many open questions currently under investigation. This review will focus on the complex multistep interplay between aging and a higher incidence of malignant hemopathies.

Keywords

Aging Elderly Tumor suppressor genes Malignant hemopathies Hematopoietic stem cell Epigenetics Senescence DNA damage repair 

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Copyright information

© Crown 2018

Authors and Affiliations

  • Vu Luan Dang Chi
    • 1
    • 2
    • 4
  • Catherine Sibille
    • 3
  • Karen Willard-Gallo
    • 2
  • Dominique Bron
    • 1
    • 4
  1. 1.Clinical and Experimental HematologyInstitut Jules Bordet, ULBBrusselsBelgium
  2. 2.Molecular Immunology UnitInstitut Jules Bordet, ULBBrusselsBelgium
  3. 3.Anatomo-pathology DepartmentInstitut Jules Bordet, ULBBrusselsBelgium
  4. 4.Department of HematologyInstitut Jules Bordet, ULBBrusselsBelgium

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