MicroRNA-125b Modulates Inflammatory Chemokine CCL4 Expression and Its Reduction May Cause CCL4 Increase in Circulation with Age

  • Nai-Lin Cheng
  • Nan-ping WengEmail author
Living reference work entry


Elevated levels of inflammatory chemokines in circulation are a hallmark of aging, but the mechanisms underlying this age-associated change are not fully understood. Recent studies suggest microRNAs play a role in the regulation of chemokine expression. Here, we review the current understanding of expression of inflammatory CC chemokine ligand 4 (CCL4) in human immune cells and its increase with aging and how reduction of microRNA-125b (miR-125b) expression contributes to the increase of CCL4 in monocytes and naïve CD8+ T cells in old adults.


miR-125b CCL4 Immune cells Aging Monocyte Naïve CD8+ T cell 


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory of Molecular Biology and Immunology, National Institute on AgingNational Institutes of HealthBaltimoreUSA
  2. 2.Lymphocyte Differentiation Section, Laboratory of Molecular Biology and ImmunologyNational Institute on Aging, National Institutes of HealthBaltimoreUSA

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