Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Myoepithelial Carcinoma of the Breast

  • Horst BürgerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-62539-3_4768

Synonyms

Malignant myoepithelioma; Metaplastic carcinoma; Spindle cell carcinoma

Definition

A malignant lesion composed of myoepithelial cells with increased mitotic activity and expression of myoepithelial markers, such as high molecular weight cytokeratins, p63, smooth muscle actin, and others.

Clinical Features

  • Incidence

    Myoepithelial carcinomas of the breast represent an extremely rare and poorly understood entity of invasive breast cancer. The exact incidence of these tumors is unknown, partially due to the disputed definition. According to the actual WHO classification, myoepithelial carcinomas are a subgroup of metaplastic carcinoma (Reis-Filho et al. 2012). Under these assumptions, the incidence is probably significantly lower than <1%.

  • Age

    Myoepithelial carcinomas have been seen in all age groups from 25 to 81 years.

  • Sex

    Rare cases of myoepithelial carcinoma of the breast have been described in women. The incidence in male patients is not known.

  • Site

    A predominant site within...

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References and Further Reading

  1. Fine, M. A., & Kurdek, L. A. (2016). An approach to the diagnosis of spindle cell lesions of the breast. Histopathology, 68, 33–44.CrossRefGoogle Scholar
  2. Reis-Filho, J. S., Lakhani, S. R., Gobbi, H., & Sneige, N. (2012). Metaplastic carcinoma. In S. R. Lakhani, I. O. Ellis, S. J. Schnitt, P. H. Tan, & M. J. van de Vijver (Eds.), WHO classification of tumours of the breast (pp. 119–124). IACR: Lyon.Google Scholar
  3. Schmitt, F., Tan, P. H., Dabbs, D., & Jones, L. (2012). Myoepithelial and epithelial–myoepithelial lesions. In S. R. Lakhani, I. O. Ellis, S. J. Schnitt, P. H. Tan, & M. J. van de Vijver (Eds.), WHO classification of tumours of the breast (pp. 119–124). IACR: Lyon.Google Scholar
  4. Schnitt, S. J., & Collins, L. C. (2009). Spindle cell lesions. In S. J. Schnitt (Ed.), Biopsy interpretation of the breast (pp. 323–343). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  5. Tan, P. H., & Ellis, I. O. (2013). Myoepithelial and epithelial–myoepithelial, mesenchymal and fibroepithelial breast lesions: Updates from the WHO Classification of Tumours of the Breast 2012. Journal of Clinical Pathology, 66, 465–470.PubMedCrossRefPubMedCentralGoogle Scholar
  6. Tavassoli, F. A., & Eusebi, V. (2009). Myoepithelial lesions. In F. A. Tavassoli & V. Eusebi (Eds.), Tumors of the mammary gland (pp. 249–262). Washington, DC: Armed Forces Institute of Pathology.Google Scholar
  7. Weidner, N., & Dabbs, J. D. (2012). Myoepithelial lesions of the breast. In D. J. Dabbs (Ed.), Breast pathology (pp. 307–323). Philadelphia: Saunders.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of Pathology Paderborn/HöxterPaderbornGermany