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Breast Pathology pp 293–300Cite as

Microinvasive Carcinoma of the Breast

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Microinvasive carcinoma, pT1mi, Invasive carcinoma less than or equal to 1 mm in greatest dimension

Definition

Microinvasive carcinoma (MIC) of the breast was not clearly characterized until 1997 when the Union for International Cancer Control (UICC) first included pT1mic in the TNM classification of breast carcinoma. It was defined as “invasive mammary carcinoma with no focus exceeding 1 mm in greatest dimension.”

This definition has been carried through many editions of the Cancer Staging Manual published by American Joint Committee on Cancer (AJCC) until the current edition (Amin et al. 2017) where it is reported as “an invasive carcinoma with no focus measured larger than 1 mm and classified as pT1mi. MIC is reported as nearly always encountered in a setting of ductal carcinoma in situ (DCIS) (Ductal Carcinoma In Situ) (Fig. 1, (a) H&E. (b) Immunostaining for smooth-muscle myosin heavy chain highlights myoepithelial cells around the DCIS, while it is absent in the...

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References and Further Reading

  • Amin, M. B., Edge, S. B., Greene, F. L., et al. (Eds.). (2017). AJCC cancer staging manual (8th ed.pp. 589–628). New York: Springer.

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  • Bianchi, S., & Vezzosi V. (2008). Microinvasive Carcinoma of the Breast. Pathology and Oncology Research, 14, 105–111.

    Article  PubMed  Google Scholar 

  • Cserni, G., Wells, C. A., Kaia, H., et al. (2016). Consistency in recognizing microinvasion in breast carcinomas is improved by immunohistochemistry for myoepithelial markers. Virchows Archive, 468, 473–481.

    Article  CAS  Google Scholar 

  • Hilson, J. B., Schnitt, S. J., & Collins, L. C. (2009). Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: Biologic and diagnostic implications. The American Journal Surgical Pathology, 33, 227–232.

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  • Hoda, S. A. (2014). Ductal carcinoma in situ. In S. A. Hoda, E. Brogi, F. C. Koerner, & P. P. Rosen (Eds.), Rosen’s breast pathology (4th ed., pp. 331–411). Philadelphia: Lippincott Williams & Wilkins.

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  • Morita, M., Yamaguchi, R., Tanaka, M., et al. (2016). Two progressive pathways of microinvasive carcinoma: Low-grade luminal pathway and high grade HER2 pathway based on high tumor-infiltrating lymphocytes. Journal of Clinical Pathology, 69, 890–898.

    Article  CAS  PubMed  Google Scholar 

  • Pinder, S. E., Ellis, I. O., Schnitt, S. J., et al. (2012). Microinvasive carcinoma. In S. R. Lakhani, I. O. Ellis, S. J. Schnitt, et al. (Eds.), WHO classification of tumours of the breast (pp. 96–97). Lyon: International Agency for Research on Cancer.

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  • Schnitt, S. J., & Collins, L. C. (Eds.). (2013). Biopsy interpretation of the breast (2nd ed.pp. 267–281). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, School of Human Health Sciences, Florence, Italy

    Simonetta Bianchi & Vania Vezzosi

Authors
  1. Simonetta Bianchi
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  2. Vania Vezzosi
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Corresponding author

Correspondence to Simonetta Bianchi .

Editor information

Editors and Affiliations

  1. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  2. Department of Medical Sciences, University of Turin, Turin, Italy

    Anna Sapino

  3. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

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Bianchi, S., Vezzosi, V. (2020). Microinvasive Carcinoma of the Breast. In: Sapino, A., Kulka, J. (eds) Breast Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-62539-3_4765

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  • DOI: https://doi.org/10.1007/978-3-319-62539-3_4765

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62538-6

  • Online ISBN: 978-3-319-62539-3

  • eBook Packages: MedicineReference Module Medicine

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