Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Atypical Ductal Hyperplasia

  • Werner BoeckerEmail author
Reference work entry


Atypical intraductal hyperplasia; Ductal intraepithelial neoplasia 1B (DIN 1B)


Atypical ductal hyperplasia (ADH) is defined as a local proliferation of evenly spaced monotonous cells with an atypical architecture, characterized by smooth geometrical growth patterns as micropapillae, arcades, Roman bridges, bars crossing the glandular space, and finally full-blown lesions with solid or cribriform growth (Fig. 1). As discussed below, the definition of ADH has undergone remarkable changes. It is the great achievement of Azzopardi who shifted our view from usual ductal hyperplasia to ductal in situ microcancer as the decisive step in early breast cancer development.
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References and Further Reading

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Gerhard Domagk-Institute of PathologyUniversity of MünsterMünsterGermany