Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Malignant Adenomyoepithelioma (M-AME)

  • Malcolm HayesEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-62539-3_4736

Synonyms

Adenomyoepithelial carcinoma; Adenomyoepithelioma with malignant transformation; Carcinoma ex-adenomyoepithelioma; Carcinoma ex-pleomorphic adenoma; Epithelial-myoepithelial carcinoma

Definition

M-AME is a malignant neoplasm of the breast that is arising within or intimately associated with a clinically and/or histologically definable benign adenomyoepithelioma or is a malignant neoplasm showing concurrent epithelial and myoepithelial differentiation. The entity of histologically benign or borderline/atypical AME associated with metastases (Nadelman et al. 2006) is not included in this definition.

Classification of M-AME

  • Epithelial-myoepithelial carcinoma (EMEC)

  • AME containing in situ carcinoma

  • AME associated with invasive carcinoma (carcinoma ex-AME):
    • Breast carcinoma of no special type (NST)

    • Invasive lobular carcinoma

    • Carcinoma of special types
      • Squamous or adenosquamous

      • Spindle cell

      • Carcinosarcoma

      • Metaplastic matrix producing

      • Myoepithelial carcinoma

Clinical Features

  • Incidence...

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References and Further Reading

  1. Ali, R. H., & Hayes, M. M. (2012). Combined epithelial-myoepithelial lesions of the breast. Surgical Pathology Clinics, 5(3), 661–699.PubMedCrossRefPubMedCentralGoogle Scholar
  2. Angèle, S., Jones, C., Reis Filho, J. S., Fulford, L. G., Treilleux, I., Lakhani, S. R., & Hall, J. (2004). Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast. Journal of Clinical Pathology, 57(11), 1179–1184.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Gatalica, Z., Velagaleti, G., Kuivaniemi, H., Tromp, G., Palazzo, J., Graves, K. M., Guigneaux, M., Wood, T., Sinha, M., & Luxon, B. (2005). Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosomes 8 and 16. Cancer Genetics and Cytogenetics, 156(1), 14–22.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Han, B., Mori, I., Nakamura, M., Wang, X., Ozaki, T., Nakamura, Y., & Kakudo, K. (2006). Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: Case report with immunohistochemical and mutational analysis. Pathology International, 56(4), 211–216.PubMedCrossRefPubMedCentralGoogle Scholar
  5. Hegyi, L., Thway, K., Newton, R., Osin, P., Nerurkar, A., Hayes, A. J., & Fisher, C. (2009). Malignant myoepithelioma arising in adenomyoepithelioma of the breast and coincident multiple gastrointestinal stromal tumors in a patient with neurofibromatosis type 1. Journal of Clinical Pathology, 62(7), 653–655.PubMedCrossRefPubMedCentralGoogle Scholar
  6. Hungermann, D., Buerger, H., Oehlschlegel, C., Herbst, H., & Boecker, W. (2005). Adenomyoepithelial tumors and myoepithelial carcinomas of the breast – A spectrum of monophasic and biphasic tumors dominated by immature myoepithelial cells. BMC Cancer, 5, 92.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Lee, S., Oh, S. Y., Kim, S.-H., et al. (2015). Malignant adenomyoepithelioma of the breast and responsiveness to eribulin. Journal of Breast Cancer, 18(4), 400–403.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Nadelman, C. M., Leslie, K. O., & Fishbein, M. C. (2006). “Benign,” metastasizing adenomyoepithelioma of the breast: A report of 2 cases. Archives of Pathology & Laboratory Medicine, 130(9), 1349–1353.Google Scholar
  9. Petrozza, V., Pasciuti, G., Pacchiarotti, A., et al. (2013). Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements. World Journal of Surgical Oncology, 11, 285.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Trojani, M., Guiu, M., Trouette, H., De Mascarel, I., & Cocquet, M. (1992). Malignant adenomyoepithelioma of the breast. An immunohistochemical, cytophotometric, and ultrastructural study of a case with lung metastases. American Journal of Clinical Pathology, 98(6), 598–602.PubMedCrossRefPubMedCentralGoogle Scholar
  11. Warrier, S., Hwang, S., Ghaly, M., & Matthews, A. (2013). Adenomyoepithelioma with ductal carcinoma in situ: A case report and review of the literature. Case Reports in Surgery, 2013, 521417.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Yoon, J. Y., & Chitale, D. (2013). Adenomyoepithelioma of the breast: A brief diagnostic review. Archives of Pathology & Laboratory Medicine, 137(5), 725–729.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Pathology DepartmentBC Cancer Agency, University of British ColumbiaVancouverCanada