Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Phyllodes Tumor

  • Mark O’LoughlinEmail author
  • Grace Callagy
Reference work entry


Benign phyllodes tumor; Benign phylloides tumor; Borderline phyllodes tumor; Borderline phylloides tumor; Cystosarcoma phyllodes; Cystosarcoma phylloides; Malignant phyllodes tumor; Malignant phylloides tumor; Phyllodes tumor; Phylloides tumor


Phyllodes tumors are true fibroepithelial neoplasms characterized by a biphasic growth pattern which comprises an epithelial and a stromal component and resembles an intracanalicular fibroadenoma. The epithelial component is double layered and arranged in clefts and is surrounded by the hypercellular stromal component. Together these give the appearance of leaflike structures. This appearance is the origin of the name cystosarcoma phyllodes when they were first described in 1838 by Müller (phyllos being the Greek word for leaf, cysto- pertaining to the cystic spaces identified, and sarcomapertaining to the sarcomatous stroma). The lesion was initially described as benign, and it was not until 1931 that its malignant...

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References and Further Reading

  1. Cimino-Mathews, A., Sharma, R., Illei, P. B., Vang, R., & Argani, P. (2014). A subset of malignant phyllodes tumors express p63 and p40: A diagnostic pitfall in breast core needle biopsies. American Journal of Surgical Pathology, 38, 1689–1696.PubMedCrossRefPubMedCentralGoogle Scholar
  2. Ellis, I., Lee, A., Pinder, S., & Rakha, E. (2013). Tumors of the breast. In C. Fletcher (Ed.), Diagnostic histopathology of tumors (4th ed., pp. 1064–1065). Philadelpia: Elsevier.Google Scholar
  3. Jara-Lazaro, A. R., Akhilesh, M., Thike, A. A., Lui, P. C.-W., Tse, G. M.-K., & Tan, P. H. (2010). Predictors of phyllodes tumours on core biopsy specimens of fibroepithelial neoplasms. Histopathology, 57, 220–232.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Tan, P. H., Tse, G., & Kee, A. (2012). Fibroepithelial tumours. In S. Lakhani, I. Ellis, S. Schnitt, P. H. Tan, & M. van de Vijver (Eds.), WHO classification of tumours of the breast (4th ed., pp. 143–147). Geneva: World Health Organisation.Google Scholar
  5. Tan, B. Y., Acs, G., Apple, S. K., Badve, S., Bleiweiss, I. J., Brogi, E., … Tan, P. H. (2016). Phyllodes tumours of the breast: A consensus review. Histopathology, 68, 5–21.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Discipline of PathologyNUI GalwayGalwayIreland
  2. 2.NUI Galway Clinical Science InstituteGalwayIreland