Breast Pathology

2020 Edition
| Editors: Anna Sapino, Janina Kulka

Polymorphous Carcinoma

  • Sofia AsioliEmail author
  • Costantino Ricci
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-62539-3_4727

Synonyms

Polymorphous low-grade adenocarcinoma

Definition

Polymorphous carcinoma is a very rare breast carcinoma with epithelial cell differentiation showing morphological features similar to those referred as polymorphous low-grade adenocarcinoma in salivary glands.

Clinical Features

  • Incidence

    Five cases of this special type of primary breast carcinoma have been reported in literature with morphological description.

  • Age

    Median age at presentation is 55 years, ranging from 37 to 74 years.

  • Sex

    All the patients reported in literature are female.

  • Site

    Breast without the prevalence of a specific mammary quadrant.

  • Treatment

    Wide excision with axillary lymph node dissection is the choice of treatment of the cases reported in the literature, followed by radiotherapy in two patients. Although no lymph node metastases are found, polymorphous carcinoma seems to be an aggressive neoplasm and recommended treatment consists of wide excision with sentinel node biopsy and eventually axillary lymph...

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References

  1. Asioli, S., Marucci, G., Ficarra, G., Stephens, M., Foschini, M. P., Ellis, I. O., & Eusebi, V. (2006). Polymorphous adenocarcinoma of the breast. Report of three cases. Virchows Archiv, 448, 29–34.PubMedCrossRefGoogle Scholar
  2. Elston, C. W., & Ellis, I. O. (1991). Pathological prognostic factors in breast cancer. 1. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology, 19, 403–410.PubMedCrossRefGoogle Scholar
  3. Foschini, M. P., Morandi, L., Asioli, S., Giove, G., Corradini, A. G., & Eusebi, V. (2017). The morphological spectrum of salivary gland type tumours of the breast. Pathology, 49, 215–227.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Reyes, C., Jorda, M., & Gomez-Fernández, C. (2013). Salivary gland-like tumors of the breast express basal-type immunohistochemical markers. Applied Immunohistochemistry and Molecular Morphology, 21, 283–286.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2020

Authors and Affiliations

  1. 1.Department of Biomedical and Neuromotor Sciences (DIBINEM)-Surgical Pathology SectionAlma Mater Studiorum – University of BolognaBolognaItaly