Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9275

Generic Name


Brand Name



Antipsychotics, second generation; bipolar agents

Proposed Mechanism(s) of Action

The efficacy of cariprazine could be mediated through a combination of partial agonist activity at central dopamine D2 and serotonin 5-HT1A receptors and antagonistic activity at serotonin 5-HT2A receptors.


For the treatment of schizophrenia and for the acute treatment of manic or mixed episodes associated with bipolar I disorder.

Off-Label Use

No common off-label use

Side Effects


Increased risk of death in elderly people with dementia-related psychosis, extrapyramidal symptoms, Parkinsonism, akathisia.


Headache, insomnia, nausea, constipation, somnolence.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA