Generic Name
Lisdexamfetamine Dimesylate
Brand Name
Vyvanse
Class
ADHD agents; stimulants
Proposed Mechanism(s) of Action
Vyvanse is a prodrug of dextroamphetamine and induces the release of dopamine and norepinephrine from their storage areas in nerve terminals.
Indication
Attention deficit/hyperactivity disorder, binge eating disorders in adults.
Off-Label Use
Treatment resistant depression.
Side Effects
Headache, hypertension, nausea, nervousness, tachycardia, angina, cardiac arrhythmia, anxiety, anger, agitation.
Serious
Psychotic episodes (particularly with IV abuse), seizures, tachycardia, hypertension, rare neuroleptic malignant syndrome, activation of manic episodes, and sudden cardiac death with those with preexisting neurocardiogenic defects.
Common
Insomnia, headache, nervousness, irritability, overstimulation, tremor, dizziness, anorexia, nausea, abdominal pain, weight loss, and blurred vision.
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Gene-based Estimate of Drug Interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList
Pill Identification. http://www.drugs.com/pill_identification.html
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Gonzalez, E.A. (2018). Lisdexamfetamine Dimesylate. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9273
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9273
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Online ISBN: 978-3-319-57111-9
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