Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Lisdexamfetamine Dimesylate

  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9273

Generic Name

Lisdexamfetamine Dimesylate

Brand Name



ADHD agents; stimulants

Proposed Mechanism(s) of Action

Vyvanse is a prodrug of dextroamphetamine and induces the release of dopamine and norepinephrine from their storage areas in nerve terminals.


Attention deficit/hyperactivity disorder, binge eating disorders in adults.

Off-Label Use

Treatment resistant depression.

Side Effects

Headache, hypertension, nausea, nervousness, tachycardia, angina, cardiac arrhythmia, anxiety, anger, agitation.


Psychotic episodes (particularly with IV abuse), seizures, tachycardia, hypertension, rare neuroleptic malignant syndrome, activation of manic episodes, and sudden cardiac death with those with preexisting neurocardiogenic defects.


Insomnia, headache, nervousness, irritability, overstimulation, tremor, dizziness, anorexia, nausea, abdominal pain, weight loss, and blurred vision.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of Psychology, Nova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA