Generic Name
Pimavanserin
Brand Name
Nuplazid
Class
Antipsychotics, second generation
Proposed Mechanism(s) of Action
Inverse agonist and antagonist activity at the serotonin 5-HT2A receptors, and some antagonist activity at the serotonin 5-HT2C receptors.
Indication
For the treatment of hallucinations and delusions associated with Parkinson’s disease.
Off-Label Use
Bipolar maintenance, bipolar depression, and behavioral disturbances in the elderly and children.
Side Effects
Serious
Increased risk of death in elderly patients with dementia-related psychosis; Q-T interval prolongation.
Common
Peripheral edema, nausea, confusion, hallucination, constipation, and gait disturbance.
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Additional Information
CenterWatch. https://www.centerwatch.com/drug-information/fda-approved-drugs/drug/100142/nuplazid-pimavanserinDrug
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com: 8080/cgi bin/ddiD4?ver=4&task=getDrugList
Interaction Effects. http://www.drugs.com/drug_interactions.html
Medscape Psychiatry
Pill Identification. http://www.drugs.com/pill_identification.html
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Gonzalez, E.A. (2018). Pimavanserin. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_9272
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DOI: https://doi.org/10.1007/978-3-319-57111-9_9272
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Publisher Name: Springer, Cham
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Online ISBN: 978-3-319-57111-9
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