Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9262

Generic Name


Brand Name



Atypical Neuroleptic, Serotonin-Dopamine Modulators (SDAM)

Proposed Mechanism(s) of Action

The efficacy of brexpiprazole may be mediated through a combination of partial agonist activity as serotonin 5-HT1A and dopamine D2 receptors, and antagonist activity at serotonin 5-HT2A receptors.


Schizophrenia, adjunctive treatment of major depressive disorder

Off Label Use

No common offlabel use

Side Effects


Increased risk of death in elderly people with dementia-related psychosis, CVA among elderly patients, hyperglycemia, low white blood cell count, orthostatic hypotension, seizures.


Headache, weight gain, somnolence, dyspepsia, constipation, fatigue, dizziness, anxiety, restlessness, increased appetite.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of Psychology, Nova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA