Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Posterior Cortical Atrophy

  • Lindsey RichardsEmail author
  • Adam J. Woods
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_9108

Posterior cortical atrophy (PCA) is a neurodegenerative progression that occurs in posterior brain regions. There is much debate on the classification of the disease. Many of the neurodegenerative qualities that transpire later on in the disease are comparable to Alzheimer’s disease (AD), but initial onset of PCA impacts different cortical areas (Mendez et al. 2002). In PCA, most affected areas of the brain occur in the occipital lobe, parietal lobe, and occipitotemporal regions. Neuroimaging of patients with PCA show a notable loss of grey matter, or atrophy, within these areas, most frequently in the occipital lobe.

Patients presenting with PCA typically have symptoms including, but not limited to: trouble grasping items in front of them, judging distances when driving, climbing stairs, seeing letters move when reading, and becoming lost in the text while reading. Onset of PCA typically occurs from mid-1950s to early 1960s with presentation of progressive visual impairment (Pantel...

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References

  1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders, 5th edition (DSM-5). Diagnostic and statistical manual of mental disorders, 5th edition TR., 280.Google Scholar
  2. Benson, D. F., Davis, R. J., & Snyder, B. D. (1988). Posterior cortical atrophy. Archives of Neurology, 45(7), 789–793.  https://doi.org/10.1001/archneur.1988.00520310107024.CrossRefPubMedGoogle Scholar
  3. Berthier, M. L., Leiguarda, R., Starkstein, S. E., Sevlever, G., & Taratuto, A. L. (1991). Alzheimer’s disease in a patient with posterior cortical atrophy. Journal of Neurology, Neurosurgery, and Psychiatry, 54(12), 1110–1111.PubMedCentralCrossRefPubMedGoogle Scholar
  4. Crutch, S. J., Lehmann, M., Schott, J. M., Rabinovici, G. D., Rossor, M. N., & Fox, N. C. (2012). Posterior cortical atrophy. Lancet Neurology.  https://doi.org/10.1016/S1474-4422(11)70289-7.PubMedCentralCrossRefPubMedGoogle Scholar
  5. Hof, P. R., Vogt, B. A., Bouras, C., & Morrison, J. H. (1997). Atypical form of Alzheimer’s disease with prominent posterior cortical atrophy: A review of lesion distribution and circuit disconnect in cortical visual pathways. Vision Research, 37(24), 3609–3625.  https://doi.org/10.1016/S0042-6989(96)00240-4.CrossRefPubMedGoogle Scholar
  6. Levine, D. N., Lee, J. M., & Fisher, C. M. (1993). The visual variant of Alzheimer’s disease: A clinicopathologic case study. Neurology, 43(2), 305–313.  https://doi.org/10.1212/WNL.43.2.305.CrossRefPubMedGoogle Scholar
  7. Lucca, U., Nobili, A., Riva, E., & Tettamanti, M. (2006). Cholinesterase inhibitor use and age in the general population. Archives of Neurology, 63(1), 154–155. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=psyc5&NEWS=N&AN=2006-00902-018.CrossRefGoogle Scholar
  8. Mendez, M. F., Ghajarania, M., & Perryman, K. M. (2002). Posterior cortical atrophy: Clinical characteristics and differences compared to Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 14(1), 33–40.  https://doi.org/10.1159/000058331.CrossRefPubMedGoogle Scholar
  9. Migliaccio, R., Agosta, F., Rascovsky, K., Karydas, A., Bonasera, S., Rabinovici, G. D., …, & Gorno-Tempini, M. L. (2009). Clinical syndromes associated with posterior atrophy: Early age at onset AD spectrum. Neurology, 73(19), 1571–1578.  https://doi.org/10.1212/WNL.0b013e3181c0d427.PubMedCentralCrossRefPubMedGoogle Scholar
  10. Pantel, J., & Schröder, J. (1996). Posterior cortical atrophy – A new dementia syndrome or a form of Alzheimer’s disease? Fortschritte der Neurologie–Psychiatrie, 64(12), 492–508.  https://doi.org/10.1055/s-2007-996595.CrossRefPubMedGoogle Scholar
  11. Rosenbloom, M. H., Alkalay, A., Agarwal, N., Baker, S. L., O’Neil, J. P., Janabi, M., …, & Rabinovici, G. D. (2011). Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution. Neurology, 76(21), 1789–1796.  https://doi.org/10.1212/WNL.0b013e31821cccad.PubMedCentralCrossRefPubMedGoogle Scholar
  12. Ross, S. J., Graham, N., Stuart-Green, L., Prins, M., Xuereb, J., Patterson, K., & Hodges, J. R. (1996). Progressive biparietal atrophy: An atypical presentation of Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 61(4), 388–395.  https://doi.org/10.1136/jnnp.61.4.388.CrossRefPubMedCentralPubMedGoogle Scholar
  13. Scheltens, P., Leys, D., Barkhof, F., Huglo, D., Weinstein, H. C., Vermersch, P., …, & Valk, J. (1992). Atrophy of medial temporal lobes on MRI in “probable” Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. Journal of Neurology, Neurosurgery, and Psychiatry, 55(10), 967–72.  https://doi.org/10.1136/jnnp.55.10.967.CrossRefGoogle Scholar
  14. Schott, J. M., Ridha, B. H., Crutch, S. J., Healy, D. G., Uphill, J. B., Warrington, E. K., …, & Fox, N. C. (2006). Apolipoprotein e genotype modifies the phenotype of Alzheimer disease. Archives of Neurology, 63(1), 155–156.  https://doi.org/10.1001/archneur.63.1.155.CrossRefGoogle Scholar
  15. Snowden, J. S., Stopford, C. L., Julien, C. L., Thompson, J. C., Davidson, Y., Gibbons, L., …, & Mann, D. (2007). Cognitive phenotypes in Alzheimer’s disease and genetic risk. Cortex, 43(7), 835–845.  https://doi.org/10.1016/S0010-9452(08)70683-X.CrossRefGoogle Scholar
  16. Tang-Wai, D. F., Graff-Radford, N. R., Boeve, B. F., Dickson, D. W., Parisi, J. E., Crook, R., …, & Petersen, R. C. (2004). Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology, 63(7), 1168–1174.  https://doi.org/10.1212/01.WNL.0000140289.18472.15.CrossRefGoogle Scholar
  17. Van Der Flier, W. M., Schoonenboom, S. N. M., Pijnenburg, Y. A. L., Fox, N. C., & Scheltens, P. (2006). The effect of APOE genotype on clinical phenotype in Alzheimer disease. Neurology, 67(3), 526–527.  https://doi.org/10.1212/01.wnl.0000228222.17111.2a.CrossRefPubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Clinical and Health PsychologyCenter for Cognitive Aging and Memory, University of FloridaGainesvilleUSA
  2. 2.Department of Clinical and Health PsychologyCollege of Public Health and Health Professions, University of FloridaGainesvilleUSA
  3. 3.Center for Cognitive Aging and MemoryMcKnight Brain Institute, University of FloridaGainesvilleUSA
  4. 4.Department of NeuroscienceUniversity of FloridaGainesvilleUSA