Eyeblink conditioning (EBC) is a form of classical conditioning of learning and memory for both human and animal subjects. There is overwhelming evidence now that the cerebellum and its associated circuitry are the necessary and sufficient circuitry for the classical acquisition and retention of the conditioned eyeblink response, which is learned for dealing with aversive stimuli (Christian and Thompson 2003). EBC paradigms have been widely used to assess learning and memory for over 50 years because the learned response is separable from the reflexive motor response, and the precision timing of the stimuli in the model results in precisely timed responses (Woodruff-Pak and Steinmetz 2000). EBC has clearly defined neuroanatomical substrates for each component of the subject’s response (Thompson and Kim 1996; Christian and Thompson 2003). The same procedures can be used in both human and animal research as little understanding is required from...
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