Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Angioma, Cavernous Angioma

  • Jennifer TinkerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_89


Cavernoma; Cavernous hemangioma; Cavernous venous malformation; Cerebral cavernous malformation (CCM)


Cavernous angiomas are benign vascular malformations found within the CNS that may occur sporadically or in a familial pattern. Cavernous angiomas are also a complication of radiation therapy, especially in children. These angiomas can remain stable, enlarge over time, or bleed, and there are no factors that predict their occurrence or behavior.

Three genetic loci responsible for familial cavernous angioma (CCM1, CCM2, and CCM3) have been identified. Cavernomas are typically found supratentorially (approximately 80%), predominantly in the subcortical rolandic and temporal areas. Infratentorially, cavernous angiomas are most commonly found in the pons and cerebellar hemispheres (Sage and Blumbergs 2001). Originally thought to be relatively rare and most commonly detected during autopsy, the advent of MRI has led to an increased detection, with incidence rates now...

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References and Readings

  1. Conway, J. E., & Rigamonti, D. (2006). Cavernous malformations: A review and current controversies. Neurosurgery Quarterly, 16(1), 15–23.CrossRefGoogle Scholar
  2. Del Curling, O., Kelly, D. L., Elster, A. D., & Craven, T. E. (1991). An analysis of the natural history of cavernous angiomas. Journal of Neurosurgery, 75(5), 702.PubMedCrossRefGoogle Scholar
  3. Sage, M. R., & Blumbergs, P. C. (2001). Cavernous haemangiomas (angiomas) of the brain. Pathological-Radiological Correlation, 45, 247–256.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyThomas Jefferson UniversityPhiladelphiaUSA