Pain asymbolia is a condition in which pain is perceived, but with an absence of the suffering that is normally associated with the pain experience. Individuals with pain asymbolia still identify the stimulus as painful but do not display the behavioral or affective reactions that usually accompany pain; no sense of threat and/or danger is precipitated by pain.
Pain asymbolia has been associated with damage to the insular cortex and the projections to the cingulate gyrus. Processing of pain involves the insular cortex receiving sensory input including pain signals from the skin and viscera. The insular cortex projects to parts of the limbic system, which gives rise to the affective component of pain. In pain asymbolia, the sensory-discriminative component of the pain processing is intact, whereas the affective-motivational component is impaired.