Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Disconnection Syndrome

  • John E. MendozaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_682


Pattern of behavioral symptoms resulting from a disruption of fiber connections between different regions of the brain.

Current Knowledge

A basic assumption in neuroanatomy is that different parts of the central nervous system subserve different functions, and if a particular region of the brain is damaged, then behaviors dependent upon that area will be disrupted. However, virtually all behavior is the result of integrated responses involving multiple areas of the brain (distributed system), and this requires that different areas of the brain communicate with one another. The exact nature of this communication is unclear, but it is known that different parts of the central nervous system interact via both short and long axonal pathways. If pathways critical for an integrated response are compromised causing relevant functional areas to be disconnected, then behaviors dependent on such interactions will be disrupted.

While any brain lesion that affects white matter tracts...

This is a preview of subscription content, log in to check access.

References and Reading

  1. Geschwind, N. (1965). Disconnexion syndromes in animals and man. Brain, 88, 237–294.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Zaidel, E., Iacoboni, M., Zaidel, D. W., & Bogen, J. E. (2003). The callosal syndromes. In K. M. Heilman & E. Valenstein (Eds.), Clinical neuropsychology (pp. 347–403). New York: Oxford University Press.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Psychiatry and NeuroscienceTulane Medical School and SE Louisiana Veterans Healthcare SystemNew OrleansUSA