Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Cushing’s Syndrome

  • Isabelle BourdeauEmail author
  • Hélène Forget
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_548

Short Description or Definition

Endogenous Cushing’s syndrome (CS) is a rare disorder occurring in about 0.2–5.0 individuals per million population per year and a prevalence of 39–79 per million in various populations (Lacroix et al. 2015). CS comprises symptoms and signs resulting from chronic supraphysiological exposure to glucocorticoids (GC). The classical clinical features of CS are centripetal obesity with abnormal fat distribution, mainly affecting the face, neck, trunk, and abdomen and sparing the extremities. Other findings are facial plethora, easy bruisability, purple abdominal striae, hirsutism, muscle weakness, hypertension, and glucose intolerance or diabetes (Nieman 2015). In addition, mood alterations and psychiatric diseases – mainly depressive and anxiety disorders as well as cognitive impairment – are highly prevalent in CS patients (Bourdeau et al. 2005).

The principal aim of this chapter is to present psychiatric and cognitive data on adult patients with CS. The...

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Authors and Affiliations

  1. 1.Division of Endocrinology, Department of MedicineResearch Centre, Centre hospitalier de l’université de Montréal (CHUM)MontrealCanada
  2. 2.Département de psychoéducation et de psychologieUniversité du Québec en OutaouaisGatineauCanada