Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Pick’s Disease

  • Suzanne MusilEmail author
  • Nancy Johnson
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_508


Behavioral variant frontotemporal dementia; Dementia of frontal lobe type; Frontal lobe dementia

Short Description or Definition

The term “Pick’s disease” has been used to describe a neuropathological entity and/or a clinical syndrome. Pathologists use this term on the basis of the histologic criteria of argyrophilic inclusions (Pick bodies) and ballooned neurons (Pick cells). As a clinical syndrome, Pick’s disease is used to describe progressive alterations in personality and behavior (e.g., frontotemporal dementia [FTD]), and/or language (e.g., progressive aphasia).


Developments in molecular pathology have led to the classification of Pick’s disease as a tauopathy, defined neuropathologically by the presence of tau immunoreactive Pick bodies (Lee et al. 2001). Compared to other tauopathies (e.g., progressive supranuclear palsy [PSP] and corticobasal degeneration [CBD]), the distribution of pathology is more likely to be cortical than subcortical, and Pick...

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Rush University Medical CenterChicagoUSA
  2. 2.Cognitive/Behavioral Neurology Center Northwestern Feinburg School of MedicineChicagoUSA