Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Lewy Bodies

  • Matthew Kraybill
  • Yana Suchy
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_503

Synonyms

Alpha-synuclein inclusions

Definition

Lewy bodies (LBs) are an abnormal aggregation of protein that develops inside the cytoplasm of neuronal cells. LBs contain ubiquitin, alpha-synuclein, and other associated enzymes (see section “ Cell Biology” below for more detail) (McKeith 2000). LBs can vary in size from 8 μm to 30 μm in diameter. There may be a single LB or multiple LBs in a particular neuron (Masterman and Swanberg 2003). They are identified microscopically using histologic staining techniques and typically appear as spherical masses that have a dense core with a surrounding halo (see Fig. 1).
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References and Readings

  1. Alvord, E. C., & Forno, L. S. (1992). Pathology. In W. C. Koller (Ed.), Handbook of Parkinson’s disease (pp. 255–284). New York: Marcel Dekker.Google Scholar
  2. Goldmann Gross, R., Siderowf, A., & Hurtig, H. I. (2008). Cognitive impairment in Parkinson’s disease and dementia with Lewy bodies: A spectrum of disease. Neurosignals, 16(1), 24–34.PubMedCrossRefGoogle Scholar
  3. Masterman, D., & Swanberg, M. (2003). Neurologic aspects of dementia with Lewy bodies and Parkinson’s disease with dementia. In P. A. Lichtenberg, D. L. Murman, & A. M. Mellow (Eds.), Handbook of dementia: Psychological, neurological, and psychiatric perspectives. Hoboken: Wiley.Google Scholar
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  6. McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O’Brien, J. T., Feldman, H., et al. (2005). Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology, 65(12), 1863–1872.PubMedCrossRefGoogle Scholar
  7. Wakabayashi, K., Tanji, K., Odagiri, S., Miki, Y., Mori, F., & Takahashi, H. (2013). The Lewy body in Parkinson’s disease and related neurodegenerative disorders. Molecular Neurobiology, 47(2), 495–508.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Matthew Kraybill
    • 1
  • Yana Suchy
    • 2
  1. 1.NeuropsychologyCottage Rehabilitation HospitalSanta BarbaraUSA
  2. 2.Department of PsychologyThe University of UtahSalt Lake CityUSA