Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Parkinson Plus Syndromes

  • Anna DePold HohlerEmail author
  • Marcus Ponce de Leon
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_472


Multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and Lewy body dementia are Parkinson plus syndromes. Individuals affected by these disorders have Parkinsonism that is more symmetric in presentation and does not respond well to Parkinson’s disease medications.


Lewy body dementia is a disease with progressive dementia and Parkinsonism. Resting tremor, if present, is minimal. Early cognitive deficits, psychiatric illness, and depression are noted. Hallucinations, paranoid delusions, rapid eye movement (REM) sleep behavior disorder, and psychotic symptoms may be present prior to anti-Parkinson medication administration and are exacerbated even by small doses of these medications. These patients typically have dramatic fluctuations in their symptoms from hour to hour or day to day. Multiple system atrophy manifests with autonomic and cerebellar symptoms or Parkinsonism without good response to anti-Parkinsonian medications....

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References and Readings

  1. Golbe, L. I. (2012). Progressive supranuclear palsy. In R. L. Watts, D. G. Standaert, & J. A. Obeso (Eds.), Movement disorders (3rd ed., pp. 409–432). New York: McGraw-Hill.Google Scholar
  2. Robottom, B. J., Shulman, L. M., & Weiner, W. J. (2012). Multiple system atrophy. In R. L. Watts, D. G. Standaert, & J. A. Obeso (Eds.), Movement disorders (3rd ed., pp. 393–408). New York: McGraw-Hill Companies, Inc..Google Scholar
  3. Stover, N. P. & Watts, R. L. (2012). Corticobasal degeneration. In R. L. Watts, D. G. Standaert & J.A. Obeso (Eds.), Movement disorders (3rd ed., pp. 433–460). New York: McGraw-Hill.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Boston University Medical CenterBostonUSA
  2. 2.Madigan Army Medical CenterTacomaUSA