Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Gamma Knife

  • Susan LadleyEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_36


Gamma knife is one of the most widely used stereotactic radiosurgery (SRS) devices. A concentrated dose of photon radiation is used to deliver the effect. Indications for gamma knife stereotactic radiosurgery include metastatic brain tumors, malignant gliomas, benign brain tumors, acoustic neuromas, arteriovenous malformations, and trigeminal neuralgia.

Current Knowledge

In metastatic disease of the brain, this procedure is most effective in patients with one to three brain tumors, but it is also suitable for individuals with multiple lesions. Good performance status, controlled primary disease, and lower total treated tumor volume have been found to be significant predictors for survival among patients with two or more brain lesions. The data suggest that SRS can be used and whole brain radiation therapy can be avoided in selected patients without loss of survival advantage.

Approximately, 95% of benign tumors may be controlled with this procedure.

In the management of...

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References and Readings

  1. Al-Quliti, K. (2015). Update on neuropathic pain treatment for trigeminal neuralgia. The pharmacological and surgical options. Neurosciences, 20(2), 107–114.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Cohen-Inbar, O., Ding, D., Chen, C.-J., & Sheehan, J. P. (2016). Stereotactic radiosurgery for deep intracranial arteriovenous malformations, part 1: Brainstem arteriovenous malformations. Journal of Clinical Neuroscience, 24, 30–36.PubMedCrossRefPubMedCentralGoogle Scholar
  3. Hatiboglu, M. A., Tuzgen, S., Akdur, K., & Chang, E. L. (2016). Treatment of high numbers of brain metastases with gamma knife radiosurgery: A review. Acta Neurochirurgica, 158(4), 625–634.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Lin, X., & DeAngelis, L. M. (2015). Treatment of brain metastases. Journal of Clinical Oncology, 33(30), 3475–3484.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Medicine and RehabilitationUniversity of Colorado, Denver Health Medical CenterDenverUSA