Synonyms
Basal ganglia-thalamocortical circuit; Cortico-basal ganglia loop
Definition
The cortical-subcortical loop describes a class of distinct, parallel circuits that connect specific regions of cerebral cortex with the basal ganglia and specific thalamic nuclei. The thalamic nuclei complete the loop by projecting back to the same regions of cortex from which the circuits originate.
Current Knowledge
Several distinct, anatomically segregated cortical-subcortical loops may be characterized based on the functional role of the cortical regions involved.
Motor Loop
The motor loop plays a role in the preparation and execution of movement. Primary motor cortex and associated premotor areas project via the putamen to the ventral tier nuclei of the thalamus, which then complete the loop with projections back to motor cortex. Somatotopic organization is maintained through all stages of this circuit.
Oculomotor Loop
The oculomotor loop is involved in the control of eye movements. The frontal...
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References and Readings
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990). Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions. Progress in Brain Research, 85, 119–146.
DeLong, M. R., & Wichmann, T. (2007). Circuits and circuit disorders of the basal ganglia. Archives of Neurology, 64(1), 20–24.
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Harris, J.L. (2018). Cortical-Subcortical Loop. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_310
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DOI: https://doi.org/10.1007/978-3-319-57111-9_310
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-57110-2
Online ISBN: 978-3-319-57111-9
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