Memory is the capacity to acquire, process, assimilate, and recall information. Memory impairment is an acquired inability to recall previously learned information or to lay down new memories.
Prior to animal studies and the development of imaging modalities, including functional MRI, knowledge regarding the formation and recollection of memory was historically gained from individual case studies. One famous case study involved patient H.M. who experienced profound amnesia following bilateral medial temporal lobe resection to control severe generalized seizures (Milner 1965, 1968). Much of his hippocampal formation, the amygdala, and adjacent medial cortex were removed or damaged. Despite premorbid above-average intelligence, he was left with profound global anterograde amnesia and moderate retrograde amnesia. Although H.M. was no longer able to intentionally recall previous experiences (explicit or declarative memory), his...
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