Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Peripheral Vascular Disease

  • Elliot J. RothEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_2222


PAD; Peripheral artery disease; PVD


Peripheral vascular disease (or peripheral artery disease) is the process by which the peripheral arteries (i.e., the arteries outside of the heart and brain) develop atherosclerosis, or the buildup of fat and cholesterol deposits called plaques, on the inside walls of the vessels.

Current Knowledge

Over time, the accumulation of plaques leads to narrowing of the artery, which causes reduced blood flow to the muscles and other tissues in that region of the body, leading to ischemia or inadequate blood supply to the tissue. When this occurs in the arteries that supply the tissues in the legs, this can produce a condition known as intermittent claudication, in which there is pain and cramping in the leg, because of inadequate blood supply. Notably, the pain occurs at the identical level of activity every time the leg is exercised. Other changes indicative of limb ischemia include changes in skin color, non-healing skin, and soft...

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References and Readings

  1. Creager, M. A., White, C. J., Hiatt, W. R., Criqui, M. H., Josephs, S. C., Alberts, M. J., et al. (2008). Atherosclerotic peripheral vascular disease symposium II. Executive summary. Circulation, 118, 2811–2825.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Medicine and Rehabilitation, Northwestern University, Feinberg School of MedicineChicagoUSA