Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Elliot J. RothEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_2205




Thrombosis is the process by which a blood clot, or thrombus, is formed.

Current Knowledge

Thrombosis can occur in any organ or tissue. It is a normal physiological response to bleeding, and helps the body to avoid excessive hemorrhage. However, in certain clinical states, thrombosis causes disease or disability. In the carotid or intracerebral blood vessels, thrombosis can cause inadequate blood supply to the brain, resulting in a stroke. In the coronary arteries, thrombosis can cause a lack of blood supply to the heart muscle, leading to a myocardial infarction or other heart conditions. Pathological thrombosis in the venous system can cause a deep vein thrombosis, which can give rise to a fatal pulmonary embolism. A thrombus is stationary at the site of its development in the blood vessel, while an embolus is a clot that moves through the bloodstream. The three predisposing factors that give rise to thrombosis are stasis of blood, hypercoaguability, and...

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References and Readings

  1. Dentali, F., Douketis, J. D., Gianni, M., Lim, W., & Crowther, M. A. (2007). Meta-analysis: Anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients. Annals of Internal Medicine, 146, 278–288.CrossRefGoogle Scholar
  2. Furie, B., & Furie, B. C. (2008). Mechanisms of thrombus formation. New England Journal of Medicine, 359, 938–949.CrossRefGoogle Scholar
  3. Hirsh, J., Guyatt, G., Albers, G. W., Harrington, R., & Schünemann, H. J. (2008). Executive summary: Antithromotic and thrombolytic therapy, 8th edition: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 133, 71S–105S.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Medicine and RehabilitationNorthwestern University, Feinberg School of MedicineChicagoUSA