Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Collagen Vascular Disease

  • Elliot J. RothEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_2170


Connective tissue disease


Collagen vascular diseases are a group of conditions that are characterized by malfunction of the tendons, bones, and connective tissue, that are supported by collagen. Their pathogenesis is autoimmune in nature.

Current Knowledge

The most common collagen vascular disorders include rheumatoid arthritis, systemic lupus erythematosus, scleroderma, and dermatomyositis. Others include polymyositis, polyarteritis nodosa, ankylosing spondylitis, and a number of vasculopathies. These diseases are frequently associated with diffuse inflammatory changes, abnormal immunity. Vascular abnormalities that result from these conditions serve as frequent causes of various types of vasculitis. Common features include arthritis, skin changes, eye changes, pericarditis, pleuritis, myocarditis, nephritis, and vasculitis of the brain, peripheral nerves, or extremities. They also may have a variety of hematological changes causing clotting or bleeding and a...

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References and Readings

  1. Klippel, J. H., Stone, J. H., Crofford, L. J., & White, P. H. (Eds.). (2008). Primer on the rheumatic diseases (13th ed.). New York: Springer.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Medicine and RehabilitationNorthwestern University, Feinberg School of MedicineChicagoUSA