Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Antiplatelet Therapy

  • Elliot J. RothEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_2157

Synonyms

Platelet anti-aggregant drugs

Definition

Antiplatelet therapy uses specific pharmacological agents (antiplatelet drugs) to inhibit the ability of platelets to clump together to form blood clots or thromboses, primarily in arteries. Antiplatelet therapy is commonly used in people with atherosclerosis (narrowing of the arteries). Platelets are naturally occurring cells (actually, portions of cells) that circulate in the blood. They clump, or aggregate, under certain conditions to initiate the formation of blood clots. These platelet clumps are then further bound together by the protein, fibrin. Together, the fibrin and the platelet clump comprise the thrombus or blood clot. Thrombi are useful in that they stop bleeding in normal circumstances. When there is a break in an artery, allowing blood to leave the vessel, platelets become activated by attaching to the wall of the blood vessel at the site of the bleeding and by attracting fibrin and other coagulation factors to the area...

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References

  1. Jhansi, K., & Vanita, P. (2014). A review on antiplatelet drugs and anticoagulants. Advance Pharmacoepidemiology Drug Safety, 3, R003.Google Scholar
  2. Tran, H., & Anand, S. S. (2004). Oral antiplatelet therapy in cerebrovascular disease, coronary artery disease, and peripheral arterial disease. Journal of the American Medical Association, 292, 1867–1874.PubMedCrossRefGoogle Scholar
  3. White, H. D. (2011). Oral anti-platelet therapy for atherothrombotic disease: Current evidence and new directions. American Heart Journal, 161, 450–461.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Medicine and Rehabilitation, Northwestern UniversityFeinberg School of MedicineChicagoUSA