Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Prefrontal Cortex

  • Paul MalloyEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1904


The frontal lobes are the portion of the cerebrum anterior to the Rolandic fissure and superior to the Sylvian fissure. The functional subdivisions of the frontal lobes include the primary motor area, premotor area, frontal eye fields, dorsolateral area, orbital area, anterior cingulate gyrus/supplementary motor areas, and basal forebrain (see Fig. 1). The primary motor area subserves pyramidal motor functions, the premotor area is involved in sensorimotor integration and praxis, and the frontal eye fields control volitional eye movement and visual search. Damage to these zones generally results in relatively simple disorders of motor functioning (e.g.,  hemiparesis, volitional gaze disturbance,  apraxia).
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References and Readings

  1. Barbas, H., & Pandya, D. N. (1989). Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey. Journal of Comparative Neurology, 286, 353–357.CrossRefGoogle Scholar
  2. Goldman-Rakic, P. (1987). Circuitry of the primate prefrontal cortex and regulation of behavior by representational memory. In F. Plum & V. Mountcastle (Eds.), Handbook of physiology, the nervous system, and higher functions of the brain. (Sect. 1 (Vol. 5, pp. 373–417). Bethesda: American Psychological Society.Google Scholar
  3. Malloy, P., & Richardson, E. (1994). Assessment of frontal lobe functions. Journal of Neuropsychiatry and Clinical Neurosciences, 6, 399–410.CrossRefGoogle Scholar
  4. Mega, M., & Cummings, J. (1994). Frontal-subcortical circuits and neuropsychiatric disorders. Journal of Neuropsychiatry and Clinical Neurosciences, 6, 358–370.CrossRefGoogle Scholar
  5. Pandya, D. N., & Barnes, C. L. (1987). Architecture and connections of the frontal lobe. In E. Perecman (Ed.), The frontal lobes revisited (pp. 41–72). New York: IRBN Press.Google Scholar
  6. Pandya, D. N., & Yeterian, E. H. (1990). Prefrontal cortex in relation to other cortical areas in rhesus monkey: Architecture and connections. In H. B. M. Uylings, C. G. Van Eden, J. P. C. DeBruin, M. A. Corner, & M. G. P. Feestra (Eds.), The prefrontal cortex: Its structure, function, and pathology, progress in brain research (Vol. 85, pp. 63–94). Amsterdam: Elsevier.CrossRefGoogle Scholar
  7. Rubin, R. D., Schwarb, H., Lucas, H. D., Dulas, M. R., & Cohen, N. J. (2017). Dynamic hippocampal and prefrontal contributions to memory processes and representations blur the boundaries of traditional cognitive domains. Brain Sciences, 7(7), 82.  https://doi.org/10.3390/brainsci7070082. Published online 12 July 2017.CrossRefPubMedCentralPubMedGoogle Scholar
  8. Salloway, S., Malloy, P., & Duffy, J. (2001). The frontal lobes and neuropsychiatric illness. Washington, DC: American Psychiatric Press.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Psychiatry and Human BehaviorBrown UniversityProvidenceUSA