Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Laura L. FrakeyEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1879


Abulia; Amotivational; Anhedonia; Negative symptom

Short Description or Definition

In the vernacular, the word apathy generally refers to indifference or a lack of feeling or concern. In clinical settings, “apathy” is often conceptualized as a lack of drive or motivation, a lack of responsiveness (behavioral or emotional) to stimuli or a lack of initiation, or a reduction in self-generated, purposeful behavior.


Apathy has been described in a variety of psychiatric, neurological, and medical conditions including depression, schizophrenia, Alzheimer’s disease, frontotemporal dementia, mild cognitive impairment (MCI), Parkinson’s disease, progressive supranuclear palsy, Huntington’s disease, cortical basal degeneration, dementia with Lewy bodies, stroke, vascular dementia, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), traumatic brain injury (TBI), anoxic encephalopathy, Wernicke-Korsakoff syndrome,...

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Further Reading

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Authors and Affiliations

  1. 1.Memorial Hospital of Rhode Island and Alpert Medical School of Brown UniversityPawtucketUSA