Multiple Sclerosis Quality of Life-54 Questionnaire

Synonyms

MSQOL-29; MSQOL-54

Definition

Multiple Sclerosis Quality of Life-54 (MSQOL-54) is considered to be the most known disease-specific instrument for the evaluation of quality of life in patients with multiple sclerosis (MS). It was developed to combine generic quality of life aspects of the SF-36 with MS-targeted dimensions and ratings for the overall quality of life (Vickrey et al. 1995). Therefore, 18 disease-specific items were added to the original 36 items of the SF-36. The added MS-specific domains are health distress (4 items), sexual function (4 items), satisfaction with sexual function (1 item), overall quality of life (2 items), cognitive function (4 items), energy (1 item), pain (1 item), and social function (1 item). The 54 items are divided into 12 multi-item and 2 single-item scales. The MSQOL-54 items are transformed linearly to 0–100 scores, and final scores are obtained by averaging items within the scales. Exploratory factor analysis confirmed two dimensions:...