Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

GABA

  • Jose A. ReyEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1765

Definition and Mechanisms of Action

Gamma(γ)-aminobutyric acid (GABA) is considered to be the major inhibitory neurotransmitter in the central nervous system (CNS). It is the product of decarboxylation, via l-glutamic acid decarboxylase (GAD), of glutamate and is thus an amino acid-derived neurotransmitter. This neurotransmitter and its respective receptors, the ionotropic GABAA receptor and the metabotropic GABABreceptor, are found throughout the CNS and are targets of drug action in an attempt to affect GABA, or its receptors, to cause anxiolytic, hypnotic, anesthetic, anticonvulsant, or muscle relaxant effects. Interestingly, GABA is derived from the same source as the brain’s most common excitatory neurotransmitter, glutamate, and often acts in opposition to glutamate to achieve a balance between excitation and inhibition at the synaptic level. The role of GABA is to bind to, and activate, a ligand-gated chloride ionophore channel complex to increase the entry of chloride ions...

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References and Readings

  1. Brunton, L. L., Chabner, B. A., & Knollman, B. C. (Eds.). (2011). Goodman & Gilman’s the pharmacological basis of therapeutics (12th ed.). New York: McGraw-Hill.Google Scholar
  2. Cooper, J. R., Bloom, F. E., & Roth, R. H. (Eds.). (2003). The biochemical basis of neuropharmacology (8th ed.). New York: Oxford University Press.Google Scholar
  3. Davis, K. L., Charney, D., Coyle, J. T., & Nermeroff, C. (Eds.). (2002). Neuropsychopharmacology: The fifth generation of progress. Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  4. Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York: Cambridge University Press.Google Scholar
  5. Voet, D., Voet, J. G., & Pratt, C. W. (Eds.). (2016). Fundamentals of biochemistry: Life at the molecular level (5th ed.). New Jersey: Wiley.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PharmacyNova Southeastern UniversityFt. LauderdaleUSA