Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Tolerance

  • Stephanie A. Kolakowsky-HaynerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1754

Synonyms

Drug resistance; Drug tolerance; Physiological tolerance

Definition

A physiological process central to drug addiction, the attenuation of or reduced response to a drug after prolonged exposure, or the ability to endure large doses of a drug. Drug tolerance increases the need for more and more drug to obtain the desired effect. While common in illicit drug use, clinicians should be aware of the potential in prescription medication as well. Prolonged use of the same prescription medication could result in physiological tolerance diminishing the intended outcome, for example, pain management. Negative or diminished results could impact mood, behavior, cognitive functioning, etc.

Cross-References

References and Readings

  1. Avanzini, G. (2006). Is tolerance to antiepileptic drugs clinically relevant? A critical commentary. Epilepsia, 47, 1285–1287.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Cheung, T., Bezzina, G., Body, S., Fone, K., Bradshaw, C., & Szabadi, E. (2007). Tolerance to the effect of 2,5-dimethoxy-4-iodoamphetamine (DOI) on free-operant timing behaviour: Interaction between behavioural and pharmacological mechanisms. Psychopharmacology, 192(4), 521–535.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Littleton, J. (2001). Receptor regulation as a unitary mechanism for drug tolerance and physical dependence – Not quite as simple as it seemed! Addiction, 96(1), 87–101.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Ramos, B., Siegel, S., & Bueno, J. (2002). Occasion setting and drug tolerance. Integrative Physiological and Behavioral Science, 37(3), 165.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Siegel, S. (2001). Pavlovian conditioning and drug overdose: When tolerance fails. Addiction Research and Theory, 9(5), 503–513.CrossRefGoogle Scholar
  6. Siegel, S. (2005). Drug tolerance, drug addiction, and drug anticipation. Current Directions in Psychological Science, 14(6), 296–300.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Rehabilitation Medicine Icahn School of Medicine at Mount SinaiNew YorkUSA