Reuptake inhibition is used to increase the amount of neurotransmitter present within the synapse. This subsequently increases the availability of that neurotransmitter to bind to the postsynaptic receptor. Reuptake inhibition effectively prevents the reabsorption of the secreted substance (typically a neurotransmitter) back into the presynaptic cell. Drugs that use reuptake inhibition as their mechanism of action include Zoloft, Paxil, and Prozac. Reuptake inhibitors are used to treat clinical depression, several anxiety disorders, and post-traumatic stress disorder. Recent studies have also yielded promising findings in the use of certain reuptake inhibitors to treat some symptoms of disorders like schizophrenia and Parkinson’s disease. Commonly used reuptake inhibitors are the selective serotonin reuptake inhibitors (SSRIs), which act to increase the availability of serotonin by inhibiting reabsorption of serotonin, therefore increasing the...
References and Readings
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