Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1715

Generic Name


Brand Name

Topamax, Epitomax, Topamac, Topimax.



Proposed Mechanism(s) of Action

Blocks voltage-sensitive sodium channels, inhibits the release of glutamate, and potentiates GABA. Theoretically inhibits carbonic anhydrase.


Partial seizures, primary generalized tonic/clonic seizures, seizures associated with Lennox-Gastaut, migraine prevention.

Off-Label Use

Bipolar mood disorder and weight management.

Side Effects


Metabolic acidosis, kidney stones, rare narrow angle closure glaucoma, hyperthermia (more frequently seen in children).


Nausea, decreased appetite, problems with concentration, reported difficulties with word-finding, sedation, asthenia, dizziness, ataxia, agitation, and visuomotor tremor.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York, NY: Cambridge University Press.Google Scholar

Additional Information

  1. Free drug online and PDA software. www.epocrates.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA