Generic Name
Thioridazine
Brand Name
Mellaril
Class
Antipsychotics, first generation; phenothiazines
Proposed Mechanism(s) of Action
Inhibits dopamine 2 receptors
Indication
Schizophrenia (treatment resistant)
Off-Label Use
Agitation (rarely used) and depressive disorders (rarely used)
Side Effects
Serious
Agranulocytosis, significant for QTc prolongation, seizures, ventricular arrhythmia, neuroleptic malignant syndrome, and sudden death
Common
Akathisia, neuroleptic-induced deficit syndrome, extrapyramidal symptoms, priapism, galactorrhea, amenorrhea, pigmentary retinopathy, sexual dysfunction, dry mouth, blurred vision, and weight gain
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Free drug online and PDA Software. www.medscape.com
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList
Pill Identification. http://www.drugs.com/pill_identification.html
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Courtney, J.C., Akins, C., Gonzalez, E.A. (2018). Thioridazine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1712
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1712
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