Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Perphenazine

  • John C. Courtney
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1691

Generic Name

Perphenazine

Brand Name

Trilafon

Class

Antipsychotics first generation, antiemetics

Proposed Mechanism(s) of Action

Dopamine 2 receptor antagonism. Also hypothesized histamine (1) antagonism and anticholinergic (M1) blockade

Indication

Schizophrenia, nausea/vomiting, and intractable hiccoughs

Off-Label Use

Other psychotic disorders and bipolar mood disorder

Side Effects

Serious

Rare neuroleptic malignant syndrome, agranulocytosis, seizures, and cardiovascular events in the elderly

Common

Akathisia, extrapyramidal symptoms, Parkinsonism, tardive dyskinesia, weight gain, dizziness, sedation, and hypotension

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA