Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1673

Generic Name


Brand Name



N-methyl-d-aspartate (NMDA) receptor antagonist

Proposed Mechanism(s) of Action

This agent appears to be a mild to moderate NMDA receptor antagonism, binding more frequently to the NMDA receptor cation channels. Via a similar action, it appears to modulate excessive glutamate release in both Alzheimer’s disease and, theoretically, post-CNS trauma.


Moderate to severe Alzheimer’s dementia

Off-Label Use

Mild to moderate Alzheimer’s dementia, memory disorders in other conditions, mild cognitive impairment, and chronic pain

Side Effects

Dizziness, confusion, headache, constipation, cough, hypertension, and somnolence


Seizures (rare)


Dizziness, headache, and constipation

References and Readings

  1. Physicians’ desk reference (71st ed.). (2017). Montvale, NJ: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.College of Psychology, Nova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA