Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

l-Tryptophan

  • Marla SanzoneEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1666

Synonyms

5-HTP; 5-hydroxytryptophan; Trp; Tryptophan; W

Indications and Definition

The term is sometimes used interchangeably with the term “tryptophan” and abbreviated “Trp” or “W.” l-Tryptophan is one of the nine essential amino acids available in most protein-based foods. Essential amino acids must be derived from food or supplements. Nonessential amino acids can be synthesized from essential or other nonessential amino acids. During digestion, l-tryptophan is broken down by intestinal bacteria that cause the odor associated with fecal material. The l-isomer from tryptophan contains the organic structural heterocyclic, indole, distinguishing it from tryptophan’s d-isomer. The l-isomer comprises the structure of the protein (IUPAC-IUB-JCBN 1983; l-Tryptophan 2009).

l-Tryptophan can be synthetically and organically derived. Synthetically, it is formulated from the bacterium, Escherichia coli, and the fermentation of serine, a nonessential organic polar amino acid, and indole....

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References and Readings

  1. (IUPAC-IUB) (JCBN) International Union of Pure & Applied Chemistry & International Union of Biochemistry & Molecular (JCBN) Joint Commission on Biochemical Nomenclature. (1983). Nomenclature and symbolism for amino acids and peptides. In: Recommendations on organic and biochemical nomenclature, symbols and terminology. Retrieved February 3, 2009, from http://www.chem.qmul.ac.uk/iupac/AminoAcid.
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  9. Tryptophan. (2003). In MedicineNet. Retrieved February 2, 2009, from http://www.medterms.com/tryptophan.
  10. Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2006). Serotonin a la carte: Supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics, 109(3), 325–338.CrossRefGoogle Scholar
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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Independent Practice, Loyola College of MarylandAnnapolisUSA